Whether you are using disposable diapers or cloth diapers, it is important to change your baby's diapers on time to avoid annoying diaper rash. Ideally, you will need to change your diaper every 2 to 3 hours or every time you feel a wet diaper. After removing the soiled diaper, be sure to clean your baby's buttocks thoroughly with a wet tissue. For baby girls, be sure to wipe from front to back to prevent the spread of bacteria that may cause infection.